Sean Maher most recently co-starred in NBC's provocative drama series The Playboy Club which Brian Grazer produced. Sean is well known to television and film audiences for his role as Dr. Simon Tam in Joss Whedon's Universal sci-fi feature Serenity and the critically acclaimed FOX series Firefly. Sean originated the role of Dr. Tam on the show, which has gained an almost cult-like fan following since it ended. His other film credits include the independent film Living 'Til the End, the story of a man who is told by a psychic of his imminent death on his next birthday. He then lives out the year as a hopeless agoraphobic, until he meets a young woman who slowly coaxes him out of his self-imposed bondage.

Sean got interested in acting after performing in a play at summer camp one year. He attended Byram Hills High School in Armonk, New York, at the same time as actors Eddie Cahill and Eyal Podell. In 1997 Sean graduated from New York University with a Bachelor of Arts in drama, and has studied theatre with the Tisch School of the Arts in London, The Collaborative Arts Project Twenty-One, Shakespeare Scenework, the Experimental Theater Wing, and the Playwright's Horizons Theater School, which he stayed with longest and has described as “home away from home”. His theatre credits include regional productions of “Doors”, “Yerma”, “Berlin, Berlin”, “Over the Tavern, Part II”, “Book of the Night”, “Severity's Mistress”, and “Into the Woods”.

Sean moved to Los Angeles after landing the coveted title role in the FOX drama Ryan Caufield: Year One. Caufield led to not only critical acclaim but a holding deal from the FOX network. Darren Star (Sex & the City) then cast Sean as Chris McConnell in the FOX series The Street. Sean also appeared in the final season of the Emmy & Golden Globe award winning series Party of Five as Neve Campbell's love interest Adam Matthews. In 2001, Sean starred opposite Mekhi Phifer in the remake of Brian's Song. The telefilm focused on real-life athlete Brian Piccolo's career with the NFL Chicago Bears and his battle and eventual death from cancer. Brian's Song was produced by Craig Zadan and Neil Meron (Chicago).

Sean reunited with Zadan and Meron in the 2006 telefilm Wedding Wars which also starred John Stamos and Eric Dane and again in 2009 when he appeared in the Lifetime series Drop Dead Diva. Sean's other television credits include roles on Human Target, The Mentalist, Warehouse 13, Make It or Break It, and The Dive From Clausen's Pier. Sean is a yoga enthusiast and LGBT advocate. He currently lives in Los Angeles with his partner and their two children.